Research confirms effectiveness of new blood pressure regime

A study from the University of Cambridge, University of Glasgow and University of Dundee, published in in the Lancet, has shown that using certain drugs in combination is more effective than using them singly for treating high blood pressure (HBP).  The drugs used in the study were amlodipine and aliskiren.

Amlodipine is a "calcium channel blocker."  It lowers blood pressure by relaxing the blood vessels, thereby easing the work of the heart muscle.  Aliskiren is a "direct renin inhibitor."  It works by decreasing certain chemicals that tighten the blood vessels.  Both are commonly used in blood pressure treatments, either individually, or in combinations with other drugs.  (Aliskirin can cause bad interactions with many other drugs.)

The study followed 1,254 patients, and found that the combination drugs produced a 25% better response and fewer side effects.


High Blood Pressure Statistics
Data is from the American Heart Association for the year 2006.  It applies only to the US; it may be loosely representative of other countries:

• In the US, about 1 in 3 adults has high blood pressure.
• Over the age of 65, women are much more likely to have HBP than men.
• There were 326,000 deaths in 2006 where HBP was a primary or contributing cause.
• The death rate for blacks was 2.5 to 3 times higher than for whites.
• From1996 to 2006 the death rate from HBP increased

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Sources:
BBC News Article
National Center for Biotechnology Information
American Heart Association - High Blood Pressure Statistics